After Isaac successfully rebuilt the sensor necessary for the experiment, Santos managed to locate thousands of signals beneath the surface with the thawed corpse.

During that time, she decrypted more of Earl Serrano's logs and learned about an individual named ' Rosetta' that was a key part of the 'Codex' mentioned by Admiral Graves. She explained that the creature was used to triangulate the Machine's signal with a sensor. Santos spearheaded the effort, excited by the new discoveries made with the frozen corpse of the creature known as the ' Nexus'. They managed to escape unharmed and proceeded with getting the experiment off the ground. On the way to the other end of the complex, the group was attacked by Unitologists from the Circle, who separated them from Isaac for a time. Santos wearing a snowsuit on Tau Volantis. She believed that if they could replicate the experiment, they could find the Machine.

Once they were safe, Santos examined the written logs left behind by the SCAF dig teams and learned about an experiment that was used to locate the Machine. Santos and the others made their way to a research facility and were attacked by a swarm of Necromorphs. Though they managed to find snow suits for each other, there were not enough for everyone, and Buckell chose to stay behind.

Hounded by the storm systems plaguing the planet, Santos and the others barely managed to make it to a bunker using flares. However, the attempt damaged the shuttle, which broke apart, separating them from Isaac in the crash. She helped Clarke work his way through the ruins of the Sovereign Colonies flotilla via RIG transmissions toward the necessary locations. Once all of the necessary parts required to repair the CMS Crozier were found, the team braved the debris and mines loitering their flight path to get down to the planet. When Isaac investigated Admiral Graves' quarters and learned about a key thought to control the Markers, she, Ellie and Buckell remained on the Roanoke and searched for a way to get down to the planet. Santos was relieved to finally meet Isaac, believing that the mission's success was likely with him present. Norton and the others reached their location within the ship, and Santos and Buckell were discovered injured by unseen events. signal on the Sovereign Colonies Armed Forces ship, the CMS Roanoke. Accompanied by Isaac Clarke, the group located Ellie's S.O.S. Thirteen days after their journey, Norton and Carver successfully made the jump to Tau Volantis.

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